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KMID : 0378019600030050095
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New Medical Journal
1960 Volume.3 No. 5 p.95 ~ p.99
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Effects of Electroshock Convulsion on the Blood Coagulation of Rabbits
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Abstract
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Evidence has been obtained in our laboratory that the activation of the sympathoadrenal system plays an
i important role in producing c}nanges in the blood picture and blood sugar of rabbits following the electroshock convulsion. In view of the fact that the activation of the sympathetic nervous system affects the blood coagulation-time, an attempt has been made to investigate the influence of the electroshock convulsion on the blood coagulation-time and the prothrombin-time in the rabbit. The electroshock convulsion was produced by the application of two electrodes on both sides of the head corresponding to the frontal areas. The elect-
i codes were connected to alternating currents of 80-100 Volts with the duration of 2-10 seconds(approximately 100-300 mAmp.). Blood samples were drawn from the jugular vein at various time intervals after electroshock and the blood coagulation-time as well as the prothrombin-time were determined by the modification of the Lee-White method and the Quick method, respectively.
1. The electroshock convulsion was followed by a prompt shortening in the blood coagulation-time and the prothrombin-time, reaching the shortest value witin 30 minutes. This acceleration of blood coagulation returned gradually to the normal level within hours.
2. Picrotoxin- and cardiazol-convulsion produced a similar shortening of blood coagulation-time as that observed after electroshock.
3. Bilateral vagotomy did not influence the shortening of the blood coagulation-time induced by electroshock.:
4. The shortening of the blood coagulation-time and the prothrombin-time was not recognized in the bilaterally adrenaleetomized rabbits after the eletroshock convulsion.
5. The pretreatment with a small dose of adrenaline appears to augment the acceleration of blood coagulation-time induced by the electroshock convulsion.
From the above restuls it may be concluded that the shortening of the blood coagulation-time and the pr ´ othrombin-time following the electroshock convulsion may be due to an increased secretion of the adrenal
gland.
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